Lecture: Small molecules to improve iPSC generation, Stefan Wölfl

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Thursday, May 17, 2018Description :
Title of lecture: Small molecules to enable, facilitate and improve iPSC generation and cell reprogramming Prof. Dr. Stefan Wölfl, University of Heidelberg, Institute for Pharmacy and Molecular Biotechnology, Germany The generation of patient specific specialized cell-types is a major task in regenerative medicine. Despite the success of genetic reprogramming protocols, it is still a challenge to generate, cultivate and expand patient specific induced pluripotent stem cells (iPSCs). The generation of iPSCs requires the expression of specific transcription factors, expression of which is maintained to conserve the pluripotent state. For reprogramming these factors are inhibited and tissue specific sets of gene expression are induced. We focus on the development of chemical compounds to replace genetic reprogramming and e.g. have identified Oct4 inducing small molecules. Although we cannot yet fully replace genetic reprogramming factors, our small molecules improve reprogramming efficiency, overcome reprogramming resistance and improve cultivation of iPSCs for reprogramming. More information about the Sartorius Research Xchange Forum on Trends and Challenges in Regenerative Medicine and Cell Therapy 2018: https://promotions.sartorius.com/rxf2018/

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