Lecture: Choloangiocyte organoids for clinical applications, Fotios Sampaziotis

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Thursday, May 17, 2018Description :
Title of lecture: Choloangiocyte organoids for clinical applications Sartorius & Science Prize Finalist 2017: Fotios Sampaziotis, M.D., Ph.D., University of Cambridge & Addenbrooke’s Hospital, UK Bile duct disorders carry significant morbidity and mortality and remain a leading cause for liver transplantation in children and adults. Despite their impact, these disorders remain poorly understood with minimal treatment options, due to the lack of appropriate model systems to study their pathogenesis and screen for new drugs. Fotios contributed to overcoming this challenge by inventing a system for culturing bile duct organoids which reproduced key features of various biliary diseases in the lab. The value of these organoids for developing new therapies became apparent when he tested multiple compounds and managed to identify a therapeutic agent which could be used as a new treatment for Cystic Fibrosis biliary disease. Furthermore, Fotios used organoids from healthy individuals and bio-degradable scaffolds to engineer human bio-artificial bile ducts in the lab. He then transplanted these engineered organs in animal models and demonstrated that they could successfully replace terminally damaged bile ducts in cases not amenable to pharmacological treatment. Fotios’ work has significant implications for the use of organoids in organ engineering and constitutes one of the first examples for the application of regenerative medicine in the context of biliary disorders. More information about the Sartorius Research Xchange Forum on Trends and Challenges in Regenerative Medicine and Cell Therapy 2018: https://promotions.sartorius.com/rxf2018/

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